Gene information
Official symbol APOB
Official full name apolipoprotein B
Gene type protein-coding gene
Chromosome2p24.1
Gene familyApolipoproteins
Resources
Entrez Gene 338
HGNC HGNC:603
Ensembl ENSG00000084674
Vega OTTHUMG00000090785
UCSC uc002red.3
GO terms: 93 records
GO Description Category LogP Number of genes Detail
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001701 in utero embryonic development GO Biological Processes -8.76987260 44 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0005319 lipid transporter activity GO Molecular Functions -5.47143795 11 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0005769 early endosome GO Cellular Components -6.25251045 19 More
GO:0005775 vacuolar lumen GO Cellular Components -10.7475427 18 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006066 alcohol metabolic process GO Biological Processes -16.7128396 29 More
GO:0006869 lipid transport GO Biological Processes -16.6388990 29 More
GO:0007276 gamete generation GO Biological Processes -2.03816629 18 More
GO:0008202 steroid metabolic process GO Biological Processes -19.3229835 29 More
GO:0008203 cholesterol metabolic process GO Biological Processes -19.4799126 22 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009743 response to carbohydrate GO Biological Processes -20.6536066 44 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0010008 endosome membrane GO Cellular Components -3.11007663 16 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010743 regulation of macrophage derived foam cell differentiation GO Biological Processes -20.3455172 15 More
GO:0010744 positive regulation of macrophage derived foam cell differentiation GO Biological Processes -12.0744578 9 More
GO:0010876 lipid localization GO Biological Processes -20.1994935 34 More
GO:0010883 regulation of lipid storage GO Biological Processes -22.5241589 19 More
GO:0010885 regulation of cholesterol storage GO Biological Processes -14.3909835 10 More
GO:0015248 sterol transporter activity GO Molecular Functions -5.41560423 6 More
GO:0015850 organic hydroxy compound transport GO Biological Processes -17.9399475 23 More
GO:0015918 sterol transport GO Biological Processes -16.3959877 17 More
GO:0016125 sterol metabolic process GO Biological Processes -19.5624674 23 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019218 regulation of steroid metabolic process GO Biological Processes -14.2494824 17 More
GO:0030135 coated vesicle GO Cellular Components -4.65185370 14 More
GO:0030136 clathrin-coated vesicle GO Cellular Components -3.00394155 9 More
GO:0030139 endocytic vesicle GO Cellular Components -10.5530816 23 More
GO:0030301 cholesterol transport GO Biological Processes -18.3843949 17 More
GO:0030662 coated vesicle membrane GO Cellular Components -3.21530675 9 More
GO:0030665 clathrin-coated vesicle membrane GO Cellular Components -2.98664168 7 More
GO:0030666 endocytic vesicle membrane GO Cellular Components -7.03002758 14 More
GO:0030669 clathrin-coated endocytic vesicle membrane GO Cellular Components -4.62709399 7 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032355 response to estradiol GO Biological Processes -15.3711017 31 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032994 protein-lipid complex GO Cellular Components -17.0133835 14 More
GO:0033344 cholesterol efflux GO Biological Processes -10.9607436 9 More
GO:0034358 plasma lipoprotein particle GO Cellular Components -17.5986271 14 More
GO:0034361 very-low-density lipoprotein particle GO Cellular Components -8.67626191 7 More
GO:0034364 high-density lipoprotein particle GO Cellular Components -15.5094832 12 More
GO:0034367 protein-containing complex remodeling GO Biological Processes -22.5554593 16 More
GO:0034368 protein-lipid complex remodeling GO Biological Processes -23.1924108 16 More
GO:0034369 plasma lipoprotein particle remodeling GO Biological Processes -23.1924108 16 More
GO:0034374 low-density lipoprotein particle remodeling GO Biological Processes -13.3517229 9 More
GO:0034377 plasma lipoprotein particle assembly GO Biological Processes -8.18952769 7 More
GO:0034381 plasma lipoprotein particle clearance GO Biological Processes -16.8165221 12 More
GO:0034385 triglyceride-rich plasma lipoprotein particle GO Cellular Components -8.67626191 7 More
GO:0034694 response to prostaglandin GO Biological Processes -5.81640478 6 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0042157 lipoprotein metabolic process GO Biological Processes -6.61578697 11 More
GO:0042158 lipoprotein biosynthetic process GO Biological Processes -1.65025617 4 More
GO:0042627 chylomicron GO Cellular Components -8.37064445 6 More
GO:0042632 cholesterol homeostasis GO Biological Processes -21.5492593 34 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043025 neuronal cell body GO Cellular Components -9.18558636 52 More
GO:0044297 cell body GO Cellular Components -11.7206640 62 More
GO:0045334 clathrin-coated endocytic vesicle GO Cellular Components -4.88495680 8 More
GO:0046486 glycerolipid metabolic process GO Biological Processes -5.86759713 18 More
GO:0046890 regulation of lipid biosynthetic process GO Biological Processes -16.6841590 23 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048844 artery morphogenesis GO Biological Processes -13.4119116 22 More
GO:0055088 lipid homeostasis GO Biological Processes -20.8046481 43 More
GO:0055092 sterol homeostasis GO Biological Processes -21.3864243 34 More
GO:0060840 artery development GO Biological Processes -12.7697342 25 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0065005 protein-lipid complex assembly GO Biological Processes -7.77416886 7 More
GO:0070325 lipoprotein particle receptor binding GO Molecular Functions -8.90426631 8 More
GO:0071379 cellular response to prostaglandin stimulus GO Biological Processes -5.51573627 5 More
GO:0071682 endocytic vesicle lumen GO Cellular Components -9.48174775 8 More
GO:0071825 protein-lipid complex subunit organization GO Biological Processes -20.9970896 17 More
GO:0071827 plasma lipoprotein particle organization GO Biological Processes -21.6197515 17 More
GO:0097006 regulation of plasma lipoprotein particle levels GO Biological Processes -27.6960426 22 More
GO:0120009 intermembrane lipid transfer GO Biological Processes -4.61583694 6 More
GO:0120013 lipid transfer activity GO Molecular Functions -4.61583694 6 More
GO:0120015 sterol transfer activity GO Molecular Functions -6.64459385 6 More
GO:0120020 cholesterol transfer activity GO Molecular Functions -6.77152389 6 More
GO:1901615 organic hydroxy compound metabolic process GO Biological Processes -22.7091625 41 More
GO:1902652 secondary alcohol metabolic process GO Biological Processes -19.9585075 23 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905954 positive regulation of lipid localization GO Biological Processes -22.7388039 24 More
GO:1990777 lipoprotein particle GO Cellular Components -17.5986271 14 More
KEGG pathways: 4 records
KEGG Description Category LogP Number of genes Detail
hsa04975 Fat digestion and absorption KEGG Pathway -5.93899775 11 More
hsa04977 Vitamin digestion and absorption KEGG Pathway -2.55598907 3 More
hsa04979 Cholesterol metabolism KEGG Pathway -20.0696655 17 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
view
Related drugs: 18 records
Drug name Interaction type Source PMID View
alcohol NCI 8576634 view
atorvastatin NCI 11882317121192029598838158641141035784012562847105371601535349812145148 view
cholestyramine NCI 3906004 view
dexamethasone NCI 7670964 view
epigalocatechin gallate NCI 11936850 view
fenofibrate NCIPharmGKB 12606523 view
heparin NCI 95216912457642 view
hydrocortisone NCI 1597147 view
irbesartan PharmGKB 15614026 view
lomitapide PharmGKB view
lovastatin NCI 235186776623191588827 view
mipomersen TdgClinicalTrial view
nevirapine NCI 12869587 view
pravastatin NCI 8312689 view
quercetin NCI 16149735 view
trifluoperazine NCI 7595077 view
vitamin e NCI 7649489 view
warfarin PharmGKB view
Related studies: 28 records
Molecular factor Omics type Application Objective MI type Reference
NC_000002.12:g.[21008652G>A;21014914T>G;21021486T>G;21022457G>T;21003688A>G] genomics myocardial infarction[diagnosis] myocardial infarction Liu C et al. Int J Clin Exp Med. 2015
NM_000384.3:c.26TGGCGCTGC[1] genomics myocardial infarction[diagnosis] myocardial infarction Visvikis S et al. Hum Genet. 1993
NM_000384.3:c.26TGGCGCTGC[1] genomics myocardial infarction[diagnosis] myocardial infarction Gardemann A et al. Atherosclerosis. 1998
APOB 3'VNTR genomics acute myocardial infarction[diagnosis] acute myocardial infarction Singh N et al. Heart Asia. 2014
NM_000384.3:c.12541G>T genomics myocardial infarction[diagnosis] myocardial infarction Hegele RA et al. N Engl J Med. 1986
NM_000384.3:c.7545C>T genomics myocardial infarction[diagnosis] myocardial infarction Hegele RA et al. N Engl J Med. 1986
NM_000384.3:c.10913G>A genomics myocardial infarction[diagnosis] myocardial infarction Hegele RA et al. N Engl J Med. 1986
NM_000384.3:c.7545C>T genomics myocardial infarction[diagnosis] myocardial infarction Bohn M et al. Clin Genet. 1993
APOB PvuII genomics myocardial infarction[diagnosis] myocardial infarction Buraczynska M et al. Med Sci Monit. 2000
apolipoprotein B-100 proteomics myocardial infarction[diagnosis] myocardial infarction Schwartzkopff W et al. Atherosclerosis. 1990
apolipoprotein B-100 proteomics old myocardial infarction[diagnosis] old myocardial infarction Durrington PN et al. Br Heart J. 1986
apolipoprotein B-100 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Maury CP et al. J Clin Pathol. 1988
apolipoprotein B-100 proteomics myocardial infarction[diagnosis] myocardial infarction Cambien F et al. Circulation. 1987
apolipoprotein B-100 proteomics myocardial infarction[diagnosis] myocardial infarction Douste-Blazy P et al. Arch Mal Coeur Vaiss. 1984
apolipoprotein B-100 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Husain M et al. Can J Cardiol. 1995
apolipoprotein B-100 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction MBewu AD et al. Atherosclerosis. 1993
apolipoprotein B-100 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Woo J et al. Int J Cardiol. 1993
apolipoprotein B-100 proteomics myocardial infarction[diagnosis] myocardial infarction Pay S et al. Int J Cardiol. 1997
apolipoprotein B-100 proteomics poor predictor acute myocardial infarction[diagnosis] acute myocardial infarction Walldius G et al. Lancet. 2001
apolipoprotein B-100 proteomics cardiovascular adverse events[prognosis (bad)] acute myocardial infarction Meisinger C et al. Eur Heart J. 2005
apolipoprotein B-100 proteomics cardiovascular adverse events[prognosis (bad)] acute myocardial infarction Meisinger C et al. Eur Heart J. 2005
apolipoprotein B-100 proteomics myocardial infarction[diagnosis] myocardial infarction Al-Muhtaseb N et al. Ann Saudi Med. 1992
apolipoprotein B-100 proteomics major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Ahmed K et al. Korean Circ J. 2012
apolipoprotein B-100 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Sharma R et al. Indian J Clin Biochem. 2001
apolipoprotein B-100 proteomics cardiovascular adverse events[prognosis (bad)] acute myocardial infarction Sokhanvar S et al. J Cardiovasc Thorac Res. 2012
apolipoprotein B-100 proteomics medium predictor myocardial infarction[diagnosis] myocardial infarction Schmidt C et al. Angiology. 2014
NC_000002.12:g.21008652G>A genomics myocardial infarction[diagnosis] myocardial infarction Liu C et al. Int J Clin Exp Med. 2015
apolipoprotein B-100 proteomics myocardial infarction[diagnosis] myocardial infarction Balling M et al. J Am Coll Cardiol. 2020
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